Proceedings of The 3rd Africa Diabetes Congress, Yaounde, Cameroon (Yaounde, 2017)

Oral presentation

Short term effects of liraglutide versus vildagliptin on insulin secretion and sensitivity in type 2 diabetes (Liravis study)

Cite this: Pan African Medical Journal - Conference Proceedings. Aug 2017; 2(2): 16. doi:10.11604/pamj.cp.2017.2.16.46

Submitted: 31 Aug 17   Accepted: 31 Aug 17   Published: 31 Aug 17

Key words: Insulin secretion, insulin sensitivity, liraglutide, vildagliptin, incretinometics

© Estelle Amandine Well et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.proceedings.panafrican-med-journal.com/conferences/2017/2/16/abstract

Corresponding author: (estelleamandinewell@gmail.com)

This abstract is published as part of the proceedings of The 3rd Africa Diabetes Congress, Yaounde, Cameroon(CAMEROON, )

Untitled Document

Short term effects of liraglutide versus vildagliptin on insulin secretion and sensitivity in type 2 diabetes (Liravis study)

Estelle Amandine Well1,2,&, Simeon Pierre Choukem3,4, Mesmin Dehayem1, Jean-Claude Njabou Katte2, Jean Claude Mbanya1,2,5, Eugene Sobngwi1,2,5

 

1National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon, 2Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon, 3Douala General Hospital, Douala, Cameroon, 4Faculty of Health Sciences, University of Buea, Buea, Cameroon, 5Laboratory of Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon

 

 

&Corresponding author
Estelle Amandine Well, National Obesity Center, Yaoundé Central Hospital, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon

 

 

Abstract

Introduction: incretinomimetics are new type 2 diabetes mellitus drugs that have the ability to increase glucose-induced insulin production. This drug class has two subclasses: Exogenous Glucagon-Like Peptide analogs (GLP1a) such as Liraglutide, and the inhibitors of Dipeptidyl peptidase IV (DPP4i) that prolong the half-life of endogenous GLP1 such as vildagliptin.We aimed to evaluate the short term metabolic effects of a GLP-1a, liraglutide versus a DPP-4i, vildagliptin on type 2 diabetes patients.

 

Methods: we conducted a randomized controlled single blind clinical trial on 14 uncontrolled type 2 diabetes patients (HbA1c = 53mmol/mol). Participants were randomly allocated in 2 groups. Anthropometric measurements, hyperinsulinemic-euglycemic clamp at 80mU/m2/min and a mixed meal tolerance test (to assess insulin sensitivity/secretion) were carried out before and after the different interventions. In group 1, 0.6mg/day of liraglutide was administered subcutaneously and increased to 1.2mg the 2nd week whereas, 100mg/day of oral vildagliptin was administered in group 2 for 2 weeks.

 

Results: after the intervention insulin sensitivity remained unchanged: liraglutide (6.6 [4.2-7.9] to 6.9 [4.3-10.8] mg/kg/min; p=0.61) and vildagliptin (7.1 [5.3- 9.0] to 6.5 [5.6-9.4] mg/kg/min; p= 0.86). LDL Cholesterol levels decreased significantly in group 1(0.85 [0.51-1.02] to 0.54 [0.50-0.73] g/L, p=0.04) but not in group 2 (p= 0.23). Concerning insulin secretion, the area under the C-peptide curve varied from (5.5[1.0-10.9] to 14.9 [10.8-17.2] nmol/L/120min, p=0.09) in group 1 and from 1.1 [0.5-14.1] to 13.0 [9.6-16.9] nmol/L/120min, p=0.17) in group 2, showing a non-significant trend towards improvement. A variation in body weight was remarked amongst the groups, being, - 0.6kg and +1.1kg in group 1 and 2 respectively.

 

Conclusion: there are no significant differences on insulin sensitivity and insulin secretion after two weeks of treatment using liraglutide and vildagliptin, in type 2 diabetes mellitus patients.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

The 3rd Africa Diabetes Congress, Yaounde, Cameroon (Yaounde)

Country: CAMEROON

Dates: 19 Apr 17 - 22 Apr 17

Venue: Yaounde Congress Hall

Organizers: Africa Diabetes Congress Limited

Secretariat: secretariat@africadiabetescongress.com

Contact person: Prof. Jean Claude Mbanya (jcmbanya@yahoo.co.uk)