Proceedings of The 3rd Africa Diabetes Congress, Yaounde, Cameroon (Yaounde, 2017)

Oral presentation

The metabolic effects of a twenty eight days add-on steviosides supplementation in type 2 diabetes mellitus patients

Cite this: Pan African Medical Journal - Conference Proceedings. Aug 2017; 2(2): 19. doi:10.11604/pamj.cp.2017.2.19.49

Submitted: 31 Aug 17   Accepted: 31 Aug 17   Published: 31 Aug 17

Key words: Steviosides, insulin secretion, insulin sensitivity, lipid profile, type 2 diabetes mellitus

© Mireille Claudia Bokam Abeng et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.proceedings.panafrican-med-journal.com/conferences/2017/2/19/abstract

Corresponding author: (mireilleclaudia_a@yahoo.fr)

This abstract is published as part of the proceedings of The 3rd Africa Diabetes Congress, Yaounde, Cameroon(CAMEROON, )

Untitled Document

The metabolic effects of a twenty eight days add-on steviosides supplementation in type 2 diabetes mellitus patients

Mireille Claudia Bokam Abeng1,&, Jean-Claude Njabou Katte2, Laure Kamguia1, Hélène Ornella Ondoa Bongha1, Jean Claude Nganou Mbanya3, Eugene Sobngwi3

 

1Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon, 2Department of public health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon, 3National Obesity Center, Yaoundé Central Hospital and Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon

 

 

&Corresponding author
Mireille Claudia Bokam Abeng, Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon

 

 

Abstract

Introduction: steviosides are natural sweeteners from Stevia rebaudiana Bertoni, with potential health benefits. However, scientific evidences are sparse on their metabolic effects in human. We aimed to evaluate the effects of Rebaudioside A on glucose metabolism and lipid profile in type 2 diabetic mellitus (T2DM) patients.

 

Methods: we carried out a non-randomized clinical trial at the National Obesity Center of the Yaoundé Central Hospital.A total of 22 patients were included in the trial, 15 patients received an add-on supplementation of 240 mg of Stevia within 28 days on their habitual anti-diabetic treatment and 7 well controlled T2DM patients on oral antidiabetic treatment were used as controls. A standard mixed meal tolerance test was performed at baseline and after 28 days in both groups. Blood glucose and C peptide concentrations were measured.

 

Results: twenty two patients (15 males and 7 females) were included in our study with a median age of 59 [52.5-62.5] years, a duration of diabetes of 5.5 [4.6-6.0] years.After 28 days, glycemic response to the mixed meal in the test and control groups was [5,3(4,8-6,4) mmol/l vs 7,1(5,8-7,8); p = 0,08] at T0, [6,3[5,6-6,8] vs 5,8 [5,2-6,8]; p = 0.09] at T30, [6,5 [5,9-7,0] vs 5,3[4,8-6,4]; p = 0.001] at T90 and [5,3[4,5-6,4] vs 6,3(5,6-7,0) mmol/l; p = 0.11] at T120. The AUC was significantly lower compared to the control group [682, 5(616,7-739,2) vs 724(675,0-847,7); p = 0,03)]. Insulin secretion was improved by 34.4% with a significant increase in the AUC compared to controls [9,6[8,7-1,3] vs 8,9(5,4-9,9) nmol/l/120 min; p = 0,02]. C-peptide and glucose disposition indicesincreased significantly (p = 0.03). Triglycerides and LDL-Cholesterol reduced significantly by 37.5% and 16% respectively (p = 0.02) after intervention.

 

Conclusion: steviosides improved post-prandial glucose by increasing insulin secretion and sensitivity and improve lipid profile in these patients. Steviosides could be considered as potential supplements in the treatment of T2DM.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

The 3rd Africa Diabetes Congress, Yaounde, Cameroon (Yaounde)

Country: CAMEROON

Dates: 19 Apr 17 - 22 Apr 17

Venue: Yaounde Congress Hall

Organizers: Africa Diabetes Congress Limited

Secretariat: secretariat@africadiabetescongress.com

Contact person: Prof. Jean Claude Mbanya (jcmbanya@yahoo.co.uk)