Proceedings of The 3rd Africa Diabetes Congress, Yaounde, Cameroon (Yaounde, 2017)

Oral presentation

Frequency and determinants of thyroid autoimmunity in Ghanaian type 2 diabetes patients: a case-control study

Cite this: Pan African Medical Journal - Conference Proceedings. Aug 2017; 2(2): 7. doi:10.11604/pamj.cp.2017.2.7.20

Submitted: 18 Aug 17   Accepted: 22 Aug 17   Published: 30 Aug 17

Key words: Thyroid autoimmunity, type 2 diabetes mellitus, associated factors

© Osei Sarfo-Kantanka et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.proceedings.panafrican-med-journal.com/conferences/2017/2/7/abstract

Corresponding author: Osei Sarfo-Kantanka, Directorate of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana (osarfokantanka21@gmail.com)

This abstract is published as part of the proceedings of The 3rd Africa Diabetes Congress, Yaounde, Cameroon(CAMEROON, )

Frequency and determinants of thyroid autoimmunity in Ghanaian type 2 diabetes patients: a case-control study

Osei Sarfo-Kantanka1,&, Fred Stephen Sarfo1,2, Eunice Oparebea Ansah1, Ernest Yorke3, Josephine Akpalu3, Bernard Nkum1,2, Benjamin Eghan1,2

 

1Directorate of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana, 2Department of Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, 3Department of Medicine, University of Ghana School of Medicine and Dentistry, Accra, Ghana

 

 

&Corresponding author
Osei Sarfo-Kantanka, Directorate of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana

 

 

Abstract

Introduction: the link between type 1 diabetes and thyroid autoimmunity is well described. The same cannot be said for type 2 diabetes where results have been mixed so far. We investigated the prevalence and determinants of thyroid autoimmunity among Ghanaian type 2 diabetes patients.

 

Methods: this was a case-control study involving 302 type 2 diabetes patients and 310 non - diabetic controls aged 40-80 years. Anthropometric and blood pressure measurements were obtained. Fasting samples were analyzed for glucose, thyroid function, and antibodies to thyroglobulin and thyroid peroxidase.

 

Results: the prevalence of thyroid autoimmunity was significantly higher among T2DM subjects (12.2% vs. 3.9%, p = 0.0004). Among T2DM subjects, 44 (14.7%) tested positive for TPOAb, 5 (1.7%) tested positive for TGAb and 15 (5.0%) tested positive for both autoantibodies. Females T2DM subjects showed a 3-fold increased risk of thyroid autoimmunity compared to males (OR:3.16, p = 0.004), T2DM subjects with hyperthyroidism had a 41% increased risk of thyroid autoimmunity (OR: 1.41, p < 0.001), sub-clinical hyperthyroidism increased the risk of thyroid autoimmunity by 2 fold, (OR:2.19, p < 0.001), subclinical hypothyroidism increased the risk of autoimmunity by 4-fold, (OR:3.57 95% p < 0.0001), and hypothyroidism was associated with a 61% increased risk of thyroid autoimmunity (OR: 1.61,1.35-2.23). Dyslipidaemia was associated with a 44% increased risk of thyroid autoimmunity (OR: 1.44, p = 0.01) and a percentage increase in HbA1c was associated with 46% increased risk of thyroid autoimmunity (OR: 1.46, p < 0.0001).

 

Conclusion: we observed a high prevalence of thyroid autoimmunity in Ghanaian T2DM subjects compared to the general population. Thyroid autoimmunity in T2DM subjects was significantly associated with female gender, thyroid dysfunction, dyslipidaemia and poor glycemic control.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

The 3rd Africa Diabetes Congress, Yaounde, Cameroon (Yaounde)

Country: CAMEROON

Dates: 19 Apr 17 - 22 Apr 17

Venue: Yaounde Congress Hall

Organizers: Africa Diabetes Congress Limited

Secretariat: secretariat@africadiabetescongress.com

Contact person: Prof. Jean Claude Mbanya (jcmbanya@yahoo.co.uk)