Proceedings of 1st Ghana Field Epidemiology and Laboratory Training Programme Scientific conference (Accra, 2017)

Oral presentation

Prevalence and factors associated with cryptococcosis infection in patients with HIV and AIDS, Esperanza Hospital, Luanda, 2016

Cite this: Pan African Medical Journal - Conference Proceedings. Oct 2017; 3(3): 24. doi:10.11604/pamj.cp.2017.3.24.126

Submitted: 05 Oct 17   Accepted: 09 Oct 17   Published: 16 Oct 17

Key words: Cryptococcosis, HIV and AIDS, Luanda

© Raidel de Jesus et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.proceedings.panafrican-med-journal.com/conferences/2017/3/24/abstract

Corresponding author: Raidel de Jesus, Angola FETP, Luanda, Angola (domjede83@gmail.com)

This abstract is published as part of the proceedings of 1st Ghana Field Epidemiology and Laboratory Training Programme Scientific conference (GHANA, )

Prevalence and factors associated with cryptococcosis infection in patients with HIV and AIDS, Esperanza Hospital, Luanda, 2016

Raidel de Jesus1,&, Miguel Santana Bettencourt Mateus1, Afonso Joana de Morais1, Pires Joao1

 

1Angola FELTP, Luanda, Angola

 

 

&Corresponding author
Raidel de Jesus, Angola FETP, Luanda, Angola

 

 

Abstract

Introduction: cryptococcosis is an infectious, systemic and opportunistic mycosis in HIV and AIDS patients. To date, few studies on Cryptococcosis and HIV and AIDS have been done in Angola. Thus, this study was carried out to determine the prevalence and factors associated with cryptococcosis infection in patients with HIV and AIDS at Hospital Esperana, a tertiary hospital, in Luanda, Angola.

 

Methods: a cross-sectional study was carried out from March 1 to June 30, 2016. The data was obtained through a semi-structured questionnaire administered to participants, and a review of clinical processes and laboratory tests. For the associated factors were using the odds ratio, Chi square test (nominal variables) or Z test (numerical variables) with 95% confidence level.

 

Results: of the 165 samples (55%) were processed, of which 33% were positive for cryptococcus and 75% were from female patients. The median age of these patients was 38 years, and 38% of the patients were from the city of Luanda. The factors associated with cryptococcal infection were: Cough (OR = 4.00; 95% CI: 2.01 - 7.93; p < 0.001); Edema (OR = 4.53, 95% CI: 1.90-10.80, p = 0.007); CD4 <100 cells/mm3 (OR = 7.81, 95% CI: 3.06-19.20, p = 0.004); TGO> 50 mg / dL (OR = 1.08, 95% CI: 1-175, p < 0.001); Anemia (OR = 6.72, 95% CI: 1.72-25.16, p = 0.004); Pneumonia (OR = 4.21, 95% CI: 1.55-11.44, p = 0.004); Tuberculosis (OR = 3.99, 95% CI: 1.74 - 9.17, p = 0.001) and Malaria (OR = 6.73, 95% CI: 2.73-20.84, p < 0.001).

 

Conclusion: the present study showed a 33% prevalence of cryptococcosis infection among the HIV and AIDS patients under follow-up in Hospital Esperana, Luanda, which might be indicative of patients presenting to care at a late stage of disease and with low CD4 cell counts. To our knowledge this is the first study that evaluated the prevalence of cryptococcosis in HIV patients in Angola and this data should inform future HIV and AIDS policies and public health strategies.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1st Ghana Field Epidemiology and Laboratory Training Programme Scientific conference (Accra)

Country: GHANA

Dates: 18 Sep 17 - 21 Sep 17

Venue: Swiss Spirit and Suites Alisa Hotels

Organizers: Ghana Field Epidemiology and Laboratory Training Programme

Secretariat: gfeltp@gmail.com

Contact person: Dr. Ernest Kenu (ernest_kenu@yahoo.com)