Proceedings of 1st International Military Congress of Tropical Medicine and Sub-Saharan Diseases (Gabès, 2017)

Abstract

Factors closely associated with prognosis of Ebola virus disease

Cite this: Pan African Medical Journal - Conference Proceedings. Nov 2017; 4(4): 42. doi:10.11604/pamj.cp.2017.4.42.247

Submitted: 13 Oct 17   Accepted: 03 Nov 17   Published: 21 Nov 17

Key words: Ebola, prognosis, factor

© Huang Lei et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.proceedings.panafrican-med-journal.com/conferences/2017/4/42/abstract

Corresponding author: Huang Lei, The 302 Hospital of PLA, China (huangleiwa@sina.com)

This abstract is published as part of the proceedings of 1st International Military Congress of Tropical Medicine and Sub-Saharan Diseases(TUNISIA, )

Factors closely associated with prognosis of Ebola virus disease

Huang Lei1,&

 

1The 302 Hospital of PLA, China

 

 

&Corresponding author
Huang Lei, The 302 Hospital of PLA, China

 

 

Abstract

Introduction: clinical and laboratory data was collected and analyzed from patients with Ebola virus disease (EVD) in Jui government hospital in Freetown, Sierra Leone, where patients with EVD were received and/or treated from Oct 1, 2014 to Jun 6, 2015.

 

Methods: EVD was confirmed by quantitative RT-PCR assays detecting serum Ebola virus (EBOV). Two hundred and eight-five patients with confirmed EVD were included in the study, and were followed up till the endpoint (recovery or death).

 

Results: among the 293 lab-confirmed EVD cases in Jui hospital, 153 recovered and 140 died, with an overall survival rate of 52.22%. Patients at the age of 6 or younger had a lower survival rate (37.5%).79.86% of the non-survivors died within 7 days after admission, 63.7% of the survivors turned serum EBOV negative 3 weeks after admission. High serum viral load was found to be predictive of patient’ non-survival outcome as indicated by the ROC curve analysis. Multivariate analyses showed that serum viral load, confusion, abdominal pain, conjunctivitis, and vomiting were factors independently associated with the outcomes of EVD patients.

 

Conclusion: most non-survival EVD patients died within 1 week after admission and patients at the age of 6 or younger had a lower survival rate. Survival patients turned negative for serum EBOV in 1-4 weeks after admission. Factors such as high serum viral load, confusion, abdominal pain, vomiting and conjunctivitis were associated with poor prognosis for EVD patients.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1st International Military Congress of Tropical Medicine and Sub-Saharan Diseases ()

Country: TUNISIA

Dates: 23 Oct 16 - 25 Oct 16

Venue:

Organizers:

Secretariat: dgsante_cmed@defense.tn

Contact person: Pr Salem Bouomrani (Salembouomrani@yahoo.fr)