Virologic response among HIV infected adults on antiretroviral therapy in a tertiary facility in Enugu, Nigeria, 2016
Izuchukwu Frank Obi1,2,&, Babatunde Adedokun3, Okechukwu Ossai4, Chinwe Chukwuka2, Kabir Sabitu1,5, Patrick Nguku1
1Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria, 2Antiretroviral Clinic University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria, 3Department of Epidemiology and Biostatistics, University of Ibadan, Nigeria State, Nigeria, 4Department of Public Health, Enugu State Ministry of Health, Enugu, Nigeria, 5Department of Community Medicine, Ahmadu Bello University, Zaria, Nigeria
Izuchukwu Frank Obi, Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria
early and sustained viral suppression with effective Antiretroviral Therapy (ART) has been linked to good clinical outcome in HIV-infected patients. Resource constraints limits pre-ART resistance testing to ensure potent customised ART in our environment. We assessed the virologic response to the first line ART regimen recommended by the national guideline.
we reviewed the records of 478 HIV infected adult patients initiated on ART in the facility between 2009 and 2014, who did not miss any drug pick-up or laboratory appointments during the first year on ART. Extracted data was analyzed with Epi Info 7. We determined the proportion of patients who achieved undetectable viraemia [viral load (VL) < 400 copies/ml] at 12 weeks and 24 weeks, compared this across different ART regimen and determined factors influencing early viral load suppression.
a total of 478 patients were studied, 310 (64.8%) were females, 346 (72.4%)
were 30-49 yrs old. While 332 (69.5%) patients achieved undetectable viraemia
at 12 weeks of ART, 356 (74.5%) achieved it at 24 weeks. After 12 weeks on
ART, 112 (74.7%) of 150 patients on Tenofovir/Emtricitabin/Efavirenz, 184 (67.1%)
of the 274 on Zidovudin/Lamivudin/Nevirapin and 32 (66.3%) of the 49 patients
on Tenofovir/Lamivudin+Nevirapin achieved undetectable viraemia (p = 0.13).
Patient age, sex, marital status, baseline CD4 count, TB co-infection status,
WHO clinical stage of disease and plasma viral load at ART initiation were
significantly associated with early viral load suppression.
there was persistence of detectable viraemia in about one third of patients after 24 weeks on recommended first-line ART in our setting. This could have implications for early virologic failure. Resistance testing prior to ART initiation is recommended. These three ART regimens have comparable effectiveness.
Nigeria CDC/Nigeria Field Epidemiology and Laboratory Training Programme 2<sup>nd</sup> Annual Scientific Conference (Abuja)
To create a platform for epidemiologists and public health physicians to share their scientific works, NCDC/NFELTP organized the 2nd annual scientific conference with the theme "strengthening one health through field epidemiology training" at Transcorp Hilton Hotel, Abuja, Nigeria from July 5-7, 2017. The objectives of the conference were to provide residents and graduates a forum to share findings from their field activities; provide training opportunity for trainees on scientific communication; provide an opportunity for epidemiological networking as well as create a forum to discuss pertinent public health issues. In attendance were dignitaries from the United States Centers for Disease Control and Prevention (CDC), USAID, WHO, Africa CDC, Ministries Departments and Agencies, University officials and other implementing partners. With the current rise in zoonotic diseases, the conference also featured a two-day pre-conference workshop on One Health which prioritized zoonotic infectious diseases in Nigeria using standardized prioritization methods. A second workshop focused on antimicrobial resistance. There were 38 oral presentations, 60 poster presentations and 2 plenary sessions. The presentations covered various sub-themes ranging from outbreak investigations, case management, health system strengthening, vaccine preventable diseases, communicable diseases and surveillance. The conference featured a National Night and climaxed with awards to outstanding presenters.
Dates: 05 Jul 17 - 07 Jul 17
Venue: Transcorp Hilton Hotel
Organizers: Nigeria Centre for Disease Control / Nigeria Field Epidemiology and Laboratory Training Programme
Contact person: Dr Patrick Nguku (firstname.lastname@example.org)