Proceedings of Nigeria Centre for Disease Control/Nigeria Field Epidemiology and Laboratory Training Programme 2nd Annual Scientific Conference (Abuja, 2018)

Opening ceremony

Lassa fever outbreak, Edo State, Nigeria, 2016

Cite this: Pan African Medical Journal - Conference Proceedings. Apr 2018; 8(8): 55. doi:10.11604/pamj.cp.2018.8.55.637

Submitted: 17 Jan 18   Accepted: 29 Jan 18   Published: 05 Apr 18

Key words: Lassa fever, haemorrhagic, epidemic-prone, viral

© Bosede Agnes Alowooye et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Corresponding author: Bosede Agnes Alowooye, Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria (

This abstract is published as part of the proceedings of Nigeria Centre for Disease Control/Nigeria Field Epidemiology and Laboratory Training Programme 2nd Annual Scientific Conference(NIGERIA, )

Lassa fever outbreak, Edo State, Nigeria, 2016

Bosede Agnes Alowooye1,&, Jude Onwujei1, Bountain Tebeda1, Ephraim Ogbaini2, Danny Asogun2, Adebola Olayinka1, Patrick Nguku1


1Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria, 2Irrua Specialist Teaching Hospital, Edo State, Nigeria



&Corresponding author
Bosede Agnes Alowooye, Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria




Introduction: Lassa fever (LF) is endemic in Nigeria with an average five-year mortality of 26%; 72.5% of confirmed cases occurred in Edo State. In January 2016, an outbreak of LF was reported in Edo State. We conducted a laboratory-based investigation to confirm, characterize and control the outbreak.


Methods: we investigated the outbreak from January to February 2016 in eight Local Government Areas in Edo State. A case was any person living in Edo State with 38°C fever for at least 2 days and some or one of the following symptoms: chest pain, sore throat, muscle pain, vomiting, and diarrhea between January and February 2016 who tested positive to Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) using S-gene and L-gene primer at Irrua Specialist Teaching Hospital (ISTH), Edo state. We line- listed cases, conducted contact tracing and assessed infection, prevention and control (IPC) at the isolation ward, ISTH. We carried out a case-control study and determined risk factors. Public health actions taken include community sensitization and stakeholders’ dialogue.


Results: of 359 suspected cases, 29 (8%) tested positive to Lassa virus. Commonest signs observed were red eyes, haematuria and facial edema. Median age of confirmed cases was 30 years (Interquartile range: 25 – 47 years). Majority 11 (37.9%) were aged 20 - 29 years, 17 (58.6%) were males and 13 (44.8%) were students. Overall, case fatality rate was 31%. Etsako West Local Government accounted for 12 (41.4%) of cases with fatality. Altogether, 179 contacts were monitored with no secondary cases. L-gene primer increased detection rate by 46.1%. Notably, IPC was below standard at the isolation ward. Late referral and development of renal complications were associated with greater likelihood of death (p < 0.005).


Conclusion: outbreak was confirmed to be Lassa fever. Late referral and renal complications were risk factors of mortality. The outbreak was similar in profile to other outbreaks in the state except for the shift from highest incidence and mortality from Esan West to Etsako West Local Government Area. Community sensitization helped to control the outbreak. We recommended continuous active surveillance and continuous sensitization.



















Nigeria CDC/Nigeria Field Epidemiology and Laboratory Training Programme 2<sup>nd</sup> Annual Scientific Conference (Abuja)

To create a platform for epidemiologists and public health physicians to share their scientific works, NCDC/NFELTP organized the 2nd annual scientific conference with the theme "strengthening one health through field epidemiology training" at Transcorp Hilton Hotel, Abuja, Nigeria from July 5-7, 2017. The objectives of the conference were to provide residents and graduates a forum to share findings from their field activities; provide training opportunity for trainees on scientific communication; provide an opportunity for epidemiological networking as well as create a forum to discuss pertinent public health issues. In attendance were dignitaries from the United States Centers for Disease Control and Prevention (CDC), USAID, WHO, Africa CDC, Ministries Departments and Agencies, University officials and other implementing partners. With the current rise in zoonotic diseases, the conference also featured a two-day pre-conference workshop on One Health which prioritized zoonotic infectious diseases in Nigeria using standardized prioritization methods. A second workshop focused on antimicrobial resistance. There were 38 oral presentations, 60 poster presentations and 2 plenary sessions. The presentations covered various sub-themes ranging from outbreak investigations, case management, health system strengthening, vaccine preventable diseases, communicable diseases and surveillance. The conference featured a National Night and climaxed with awards to outstanding presenters.

Country: NIGERIA

Dates: 05 Jul 17 - 07 Jul 17

Venue: Transcorp Hilton Hotel

Organizers: Nigeria Centre for Disease Control / Nigeria Field Epidemiology and Laboratory Training Programme


Contact person: Dr Patrick Nguku (