Proceedings of Nigeria Centre for Disease Control/Nigeria Field Epidemiology and Laboratory Training Programme 2nd Annual Scientific Conference (Abuja, 2018)

Opening ceremony

Outbreak of cerebrospinal meningitis due to Neisseria meningitidis serogroup C, Sokoto State, Nigeria - May 2017

Cite this: Pan African Medical Journal - Conference Proceedings. Mar 2018; 8(8): 7. doi:10.11604/pamj.cp.2018.8.7.589

Submitted: 12 Jan 18   Accepted: 29 Jan 18   Published: 21 Mar 18

Key words: Meningitis, Sokoto State, risk factors

© Assad Hassan et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Available online at: http://www.proceedings.panafrican-med-journal.com/conferences/2018/8/7/abstract

Corresponding author: Assad Hassan, Nigeria Field Epidemiology and Laboratory Training Program, Asokoro, Abuja, Nigeria (hssnassad@yahoo.com)

This abstract is published as part of the proceedings of Nigeria Centre for Disease Control/Nigeria Field Epidemiology and Laboratory Training Programme 2nd Annual Scientific Conference(NIGERIA, )

Outbreak of cerebrospinal meningitis due to Neisseria meningitidis serogroup C, Sokoto State, Nigeria - May 2017

Assad Hassan1,&, Garba Mustapha1, Rahmatu Abdu-aguye1, Kassim Abdulmumini1, Bola Lawal1, Usman Yashe2, Halimatu Ayanleke3, Mahmood Dalhat1

 

1Nigeria Field Epidemiology and Laboratory Training Program, Abuja, Nigeria, 2Nigeria Centre for Disease Control, Abuja, Nigeria, 3African Field Epidemiology Network, Nigeria

 

 

&Corresponding author
Assad Hassan, Nigeria Field Epidemiology and Laboratory Training Program, Asokoro, Abuja, Nigeria

 

 

Abstract

Introduction: between 2013 and 2016, consecutive outbreaks of cerebrospinal meningitis (CSM) caused by a new strain of Neisseria meningitidis serogroup C (NmC) led to a reported 7,583 cases and 434 deaths in Northwest Nigeria with 1536 cases and 87 deaths from Sokoto state. In March, 2017 a suspected outbreak of CSM was reported in Sokoto State. We investigated the outbreak to describe the epidemiology, identify risk factors, and recommend preventive measures.

 

Methods: we conducted a 1:1 unmatched case-control study using a structured questionnaire to identify risk factors. We defined a suspected case as any resident of Sokoto, with sudden onset of fever (> 38.5C rectal or 38.0C axillary) and one of the following signs; neck stiffness, altered consciousness, vomiting, diarrhea and/or other meningeal signs including bulging fontanelle in toddlers between February 27 and May 3, 2017. We identified cases at treatment camps and through active case search. Cerebrospinal fluid (CSF) samples were collected for laboratory investigations.

 

Results: we recorded 133 cases with attack rate 89.7 per 100,000. 73 (56%) were female. Mean age (standard deviation) 16 (10.1) years. Bivariate analysis revealed socio-economic status (OR = 3.5 [95% CI = 2.1-5.8]) and previous vaccination against CSM (OR = 2.5 [95% CI = 1.4-4.5]) were associated with the outbreak. On multivariate analysis, socio-economic status (aOR = 2.80 [95% CI = 1.61-4.87]) and previous vaccination against CSM (aOR = 2.05; [95% CI = 1.05-3.99] ) emerged as independent risk factors of CSM in the outbreak. Of the 84 CSF samples collected, 11 (13%) had NmC isolated.

 

Conclusion: this was an outbreak of CSM due to NmC associated with low socio-economic status and previous vaccination against CSM. We supported enhanced case-based surveillance, standard case management, and reactive vaccination with meningococcal C conjugate vaccines. We recommend targeted health promotion campaigns in poor communities and regional vaccination campaigns with a long lasting meningococcal C conjugate vaccine to curtail the current outbreak and to prevent future outbreaks.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Nigeria CDC/Nigeria Field Epidemiology and Laboratory Training Programme 2<sup>nd</sup> Annual Scientific Conference (Abuja)

To create a platform for epidemiologists and public health physicians to share their scientific works, NCDC/NFELTP organized the 2nd annual scientific conference with the theme "strengthening one health through field epidemiology training" at Transcorp Hilton Hotel, Abuja, Nigeria from July 5-7, 2017. The objectives of the conference were to provide residents and graduates a forum to share findings from their field activities; provide training opportunity for trainees on scientific communication; provide an opportunity for epidemiological networking as well as create a forum to discuss pertinent public health issues. In attendance were dignitaries from the United States Centers for Disease Control and Prevention (CDC), USAID, WHO, Africa CDC, Ministries Departments and Agencies, University officials and other implementing partners. With the current rise in zoonotic diseases, the conference also featured a two-day pre-conference workshop on One Health which prioritized zoonotic infectious diseases in Nigeria using standardized prioritization methods. A second workshop focused on antimicrobial resistance. There were 38 oral presentations, 60 poster presentations and 2 plenary sessions. The presentations covered various sub-themes ranging from outbreak investigations, case management, health system strengthening, vaccine preventable diseases, communicable diseases and surveillance. The conference featured a National Night and climaxed with awards to outstanding presenters.

Country: NIGERIA

Dates: 05 Jul 17 - 07 Jul 17

Venue: Transcorp Hilton Hotel

Organizers: Nigeria Centre for Disease Control / Nigeria Field Epidemiology and Laboratory Training Programme

Secretariat: gchinyere@afenet.net

Contact person: Dr Patrick Nguku (pnguku@afenet.net)