Conference abstract

Is cystatin C also a marker of chronic periodontitis in type 2 diabetes?

Pan African Medical Journal - Conference Proceedings. 2021:11(15).20 Dec 2021.
doi: 10.11604/pamj-cp.2021.11.15.916

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Keywords: Cystatin C, periodontitis, diabetes
Oral presentation

Is cystatin C also a marker of chronic periodontitis in type 2 diabetes?

Marie Hortense Essomba, Martine Etoa Etoga, Elodie Edinga, Assiga Ntsama Antoinette, Winnie Isabelle Mboutchuin, Daryl Tcheutchoua Nzokou, Njeatih Linda Umeyugho, Vicky Ama Moor, Sobngwi Eugène, Jean-Claude Mbanya

1National Obesity Center, Endocrine and metabolic diseases unit. Central Hospital of Yaoundé, Yaoundé, Cameroon, 2Centre Pasteur du Cameroun, Yaoundé, Cameroun, 3University Teaching Hospital of Yaoundé, Yaoundé, Cameroon, 4Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon, 5Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon

&Corresponding author

INTRODUCTION: Cystatin C is a biomarker that is believed to be involved in the inflammatory process and has a protective role against tissue destruction. It is also an early marker of the micro and macrovascular complications of type 2 diabetes (T2DM). Periodontitis is a common complication found in patients with T2DM. Therefore, could cystatin C also be a marker of chronic periodontitis in people with T2DM? METHODS: we conducted a cross-sectional analytical study in 140 patients with T2DM at the Yaoundé National Obesity Centre. We performed an odontostomatological examination and serum determinations of cystatin C by the immunoturbidimetric method and glycated hemoglobin. The t Test was used for the comparison of averages. RESULTS: we included 49 men and 91 women aged 55[49-65] years. The median duration of diabetes was 3[0-9] years. Serum glycated hemoglobin levels found in patients with and without periodontitis were 7.5 ± 2.6 vs 5.4 ± 0.6% (p = 0.49), respectively. Serum cystatin C levels were 0.8 ± 0.2 vs. 0.9±0.1 mg/L (p = 0.19). CONCLUSION : although cystatin C is a marker of microvascular and macrovascular complications of T2DM, a significant association with chronic periodontitis has not been found.