Conference abstract

Seroprevalence of hepatitis B and hepatitis C viruses among diabetes mellitus patients

Pan African Medical Journal - Conference Proceedings. 2021:11(23).30 Dec 2021.
doi: 10.11604/pamj-cp.2021.11.23.936

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Keywords: Hepatitis B virus, hepatitis C virus, diabetes mellitus, Ethiopia
Poster

Seroprevalence of hepatitis B and hepatitis C viruses among diabetes mellitus patients

Alebachew Fasil1,&, Demeke Geremew2, Gezahegn Bewuket2, Amare Kifle2, Molla Abebe1, Belete Biadgo1

1University of Gondar, College of Medicine and Health Sciences School of Biomedical and Laboratory Sciences, Department of Clinical Chemistry, Gondar, Ethiopia, 2University of Gondar, College of Medicine and Health Sciences School of Biomedical and Laboratory Sciences, department of Immunology and Molecular biology, Gondar, Ethiopia

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Introduction: hepatitis viruses are common infections and main causative agents of chronic liver diseases, cirrhosis and hepatocellular carcinoma. Liver is major site of hormone and glucose metabolism having deep interconnection with diabetes. Hepatitis-B and hepatitis-C virus infection and diabetes, are prevalent diseases worldwide associated with increased morbidity and mortality. High prevalence of DM and HCV and HBV showed that there is higher chance of coexisting in an individual. Therefore our study tried to assess coexistence of hepatitis viruses and diabetes mellitus among DM patients at university of Gondar hospital. Methods: hospital based cross sectional study was conducted from November 01 to December 30/ 2017 to assess prevalence and associated factors of HBV & HCV among diabetes patients attending at University of Gondar referral hospital. Sociodemographic data collected using semi structured questionnaire. Four milliliter of blood collected using anticoagulant free test tube for biochemical and hepatitis viruses´ detection. HBsAg and HCV anti-body detection performed by using One Step Cassette Style HBsAg Rapid Test and EUGENE® anti-HCV rapid test, respectively. Binary and multivariable logistic regression models were used to evaluate associated risk factors for the outcome variable. A P-value of < 0.05 was considered as statistically significant. Results: total of 288 diabetes patients included for this study and prevalence of HBV & HCV was 7(2.43%) & 18(6.25%) respectively. Hepatitis B virus showed similar prevalence for type 1 and type 2 diabetes 2.6% and 2.3% respectively, but HCV showed wide variation 17.5% and 4.3% prevalence respectively for both diabetes types. In multivariable logistic regression model 25-44 years (AOR: 19.145, 95% CI: -0.737-22.059), 45-64 years (AOR: 19.277, 95% CI: 13.350 - 22.383)), ≥ 65 years (AOR: 19.545, 95% CI: 2.577-22.827) age groups and poor glycemic control (AOR: 18.84, 95% CI: 17.83-20.39) showed significant association with HBV. Conclusion: considerably large number of diabetes patients infected with hepatitis viruses and older ages and diabetes patients having poor glycemic control showed significant association with HBV and HCV.