Conference abstract

Clinical features of diabetic patients with chronic kidney disease in a referral hospital in Cameroon: a comparative study

Pan African Medical Journal - Conference Proceedings. 2021:11(4).04 Dec 2021.
doi: 10.11604/pamj-cp.2021.11.4.1043

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Keywords: Chronic Kidney Disease, Diabetes, Douala, Cameroon
Poster

Clinical features of diabetic patients with chronic kidney disease in a referral hospital in Cameroon: a comparative study

Halle Marie Patrice1,2, Djantio Hilaire2, Kaze Folefack Fran├žois3, Fouda Hermine2,3, Choukem Simeon Pierre2,4, shuntantang Gloria3

1Faculty of Medicine and Pharmaceutical Sciences, University of Douala; Cameroon, 2Department of Internal Medicine, Douala General Hospital, Douala, Cameroon, 3Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon, 4Faculty of Medicine and Pharmaceutical sciences; University of Dschang, Dschang, Cameroon

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Background : Chronic kidney disease (CKD) is a public health problem and diabetes is the leading cause in the world. The aim of this study was to determine the characteristics of diabetic patients with CKD compared to a control group in a tertiary hospital in Cameroon.

Methodology : A retrospective study including 238 diabetic patients referred for CKD in the nephrology unit of the Douala General Hospital in the littoral region of Cameroon from January 2007 to December 2016. They were matched with 476 (1:2) non diabetics CKD patients by years of consultation. Relevant socio demographics and clinical data were collected from medical records. CKD was define by eGFR <60ml/min/1.73m2 and/or proteinuria >1+ and /or abnormal ultrasound persistent for more than 3 months. Diabetes was defined as a fasting blood glucose >1.26g/l or HbA1C> 6.5% or the use of hypoglycaemic agents.

Results : CKD patients were mainly men in both groups (66.4% vs 63%, p= 0.377). Compared to the control group, diabetics patients were older (mean age 58.96 vs 47.29, p< 0.001), more hypertensive (83.5% vs 67.2%, p<0.001), and proteinuric (75.6%/56.9%, p<0.001) used more NSAID (38.2%/27.3%, p=0.007). In the group of diabetic patients median hemoglobin level (9.6g/dl vs 10.01g/dl, p=0.035), phosphoremia (43.32mg/l vs 48.69mg/l, p=0.001), total cholesterol (1.83g/l vs 2.03g/l, p=0.001) and uricemia (82.3mg/l vs 85.6mg/l, p=0.01) were significantly lower compared to non diabetics one. Prevalence of hepatitis C antibody was significantly higher in diabetic patients (27.7% vs 21%, p= 0.0045) than in control group.

Conclusion: Diabetics patients with CKD in our setting are older and had various clinical and biological difference compared to non-diabetics CKD patients.

Keywords: Chronic Kidney Disease, Diabetes, Douala, Cameroon