Conference abstract
Evaluation of SARS-COV-2 immune response in vaccinated healthcare workers
Pan African Medical Journal - Conference Proceedings. 2023:18(18).03
Oct 2023.
doi: 10.11604/pamj-cp.2023.18.18.2065
Archived on: 03 Oct 2023
Contact the corresponding author
Keywords: SARS-CoV-2, seropositivity, vaccination, health care workers
Oral presentation
Evaluation of SARS-COV-2 immune response in vaccinated healthcare workers
Nsah Bongdze-Em Lilian1,2,&, Ngomtcho Sen Claudine Henriette1,3, Nfor Nadin Beri1,4, Angyiba Serges Andigena1, Gesu C3, Kom X2, Noubom Michel1, Ateudjieu Jérome6
1Department of Microbiology, Hematology and Immunology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon, 2Regional Hospital of Bafoussam, Bafoussam, Cameroon, 3National Public Health Laboratory, Yaoundé, Cameroon, 4Regional Hospital of Bamenda, Bamenda, Cameroon, 5Blood Bank Unit, Medical laboratory Service, Bafoussam Regional Hospital, Bafoussam, Cameroun, 6Department of Public health, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon
&Corresponding author
Introduction: Healthcare workers (HCWs) are on the frontline of the COVID-19 pandemic and are therefore permanently exposed to the risk of nosocomial infection and to expose care seekers to the same risk. The objective of this study is to assess the SARS-CoV-2 Immune response in vaccinated HCWs in 2022 in the MIFI Health District.
Methods: a hospital-based cross-sectional study was conducted from March to May 2022 targeting HCWs from seven selected health facilities of the Mifi Health District. PCR assay to detect SARS-CoV-2 from nasopharyngeal swabs and ELISA technique for quantification of anti-SARS-CoV-2 IgG antibodies from blood were performed. The frequency of health personnel exposed to vaccination and of those tested with SARS-CoV-2 antibodies were estimated. We also assessed the statistical relationship between exposure to vaccination and having SARS-CoV-2 antibodies.
Results: the study enrolled 203 HCWs including 13 Medical doctors and 90 nurses, 64 laboratory technicians, 36 non-clinical staff with 41.38% aged 31-40 years. Of them, 68 (33.50%) were declared to have been vaccinated. 64/ 203 HCWs (31.5%) were tested to have anti-SARS-CoV-2 antibodies. Among 37(65%) who were vaccinated in a time frame of less than 3 months, 21(32.8%) of those exposed to Johnson & Johnson had detectable anti-SARS-CoV-2 IgG. There was a significant association between vaccination and the presence of SARS-CoV-2 antibody (P<0.05). Among 64(31.5%) with detectable antibodies, 30(44, 12%) were vaccinated, 16(29.09 %) naturally infected and 38(40%) asymptomatic.
Conclusion: vaccinated people are more likely than unvaccinated people to have an immune response characterized by the presence of SARS-CoV-2 antibody probably associated to the protection against the transmission of the related disease.
Evaluation of SARS-COV-2 immune response in vaccinated healthcare workers
Nsah Bongdze-Em Lilian1,2,&, Ngomtcho Sen Claudine Henriette1,3, Nfor Nadin Beri1,4, Angyiba Serges Andigena1, Gesu C3, Kom X2, Noubom Michel1, Ateudjieu Jérome6
1Department of Microbiology, Hematology and Immunology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon, 2Regional Hospital of Bafoussam, Bafoussam, Cameroon, 3National Public Health Laboratory, Yaoundé, Cameroon, 4Regional Hospital of Bamenda, Bamenda, Cameroon, 5Blood Bank Unit, Medical laboratory Service, Bafoussam Regional Hospital, Bafoussam, Cameroun, 6Department of Public health, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon
&Corresponding author
Introduction: Healthcare workers (HCWs) are on the frontline of the COVID-19 pandemic and are therefore permanently exposed to the risk of nosocomial infection and to expose care seekers to the same risk. The objective of this study is to assess the SARS-CoV-2 Immune response in vaccinated HCWs in 2022 in the MIFI Health District.
Methods: a hospital-based cross-sectional study was conducted from March to May 2022 targeting HCWs from seven selected health facilities of the Mifi Health District. PCR assay to detect SARS-CoV-2 from nasopharyngeal swabs and ELISA technique for quantification of anti-SARS-CoV-2 IgG antibodies from blood were performed. The frequency of health personnel exposed to vaccination and of those tested with SARS-CoV-2 antibodies were estimated. We also assessed the statistical relationship between exposure to vaccination and having SARS-CoV-2 antibodies.
Results: the study enrolled 203 HCWs including 13 Medical doctors and 90 nurses, 64 laboratory technicians, 36 non-clinical staff with 41.38% aged 31-40 years. Of them, 68 (33.50%) were declared to have been vaccinated. 64/ 203 HCWs (31.5%) were tested to have anti-SARS-CoV-2 antibodies. Among 37(65%) who were vaccinated in a time frame of less than 3 months, 21(32.8%) of those exposed to Johnson & Johnson had detectable anti-SARS-CoV-2 IgG. There was a significant association between vaccination and the presence of SARS-CoV-2 antibody (P<0.05). Among 64(31.5%) with detectable antibodies, 30(44, 12%) were vaccinated, 16(29.09 %) naturally infected and 38(40%) asymptomatic.
Conclusion: vaccinated people are more likely than unvaccinated people to have an immune response characterized by the presence of SARS-CoV-2 antibody probably associated to the protection against the transmission of the related disease.
